![]() Interestingly, the origin of the Latin name of Symphytum L. has centuries-old diverse usages in traditional medicine. genus were selected to focus on anti-inflammatory effects. In this review, among the numerous herbal products used in traditional medicines to manage disorders, plants of Symphytum L. Since ere could be some potential side effects, contraindications, and severe drug-herb interactions through the use of herbal medicines, it is necessary to control and monitor the safety and effectiveness of those medicinal herbs ( 10, 11). There is a prevalent tendency to use medicinal herbs for the treatment of disorders ( 9). ![]() Their use is grounded either in traditional medicine or modern medicine ( 8). Most developed or developing countries have herbal pharmacopeia separately in addition to the usage of herbal products in the treatment procedure by the health care team, there is the more widespread usage of unofficial herbal treatments among the people in the society. The synergistic effect may occur and impress the targeted elements of the molecular pathways ( 7). Unlike the drugs (SAID and NSAID), which pose an impact by a single component, medicinal plants might act by multitudes of different active compounds. Therefore, there is a need for different and safe anti-inflammatory medicines, and one of the current and essential research candidates is herbal products ( 6). In addition, patients suffering from adverse effects of the mentioned drugs, such as gastrointestinal disorders, ulcers, and liver disease, will increase, consequently ( 5). These medications have not been fully efficient for treating chronic inflammatory complaints they temporarily suppress the diseases. Drugs such as steroidal anti-inflammatory drugs (SAID) and non-steroidal anti-inflammatory drugs (NSAID) are usually utilized for the treatment of acute inflammatory complaints ( 3, 4). Inflammation could be classified into two groups, acute and chronic inflammation, and each possesses certain types of treatments. Inflammation is generally characterized by redness, edema, fever, and pain, which might bring about loss of organ function dealing with the involved tissue ( 2). It must be controlled precisely since insufficiencies or excesses of the inflammatory response could cause morbidity, shorten lifetime and decrease quality of life ( 1). ![]() Inflammation is a local, protecting reaction to injury or microbial invasion. The Symphytum genus is waiting for researchers to develop safe and effective anti-inflammatory agents for additional investigation of other different mechanisms of action. This review may provide a scientific base for establishing innovative and alternative techniques for isolating a single individual from this genus to attenuate inflammatory disorders. The papers with the English language were gathered from 2000 to 2021. This review presents an overview of the anti-inflammatory activities of different products and bioactive constituents in this genus. ![]() Preclinical and clinical trials have reported the prevailing anti-inflammatory effect of several Symphytum species. Symphytum spp.’s active components, such as allantoin, polyphenols, flavonoids, and alkaloids, can act on several intentions in the signaling pathway, constrain pro-inflammatory enzymes, reducing the construction of inflammatory chemokine’s and cytokines, and decreasing oxidative stress, which afterward suppresses inflammation procedures. ![]() The Symphytum genus has been mainly used in traditional medicine, containing its anti-inflammatory activity. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |